2. Metabolic Disease

Metabolic Disease

Metabolic Disease

Related Products

PDF 53.7 MB

Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N2099
    Onjisaponin B 35906-36-6 99.31%
    Onjisaponin B is an orally active natural product derived from Polygala tenuifolia. Onjisaponin B inhibits NF-κB p65. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin. Onjisaponin B reduces β-amyloid (Aβ) production. Onjisaponin B reduces radiation-induced cell apoptosis. Onjisaponin B has anti-oxidant and anti-inflammatory activities. Onjisaponin B can be used for neurological disease and radiation injury study, and its metabolite tenuifolin (TF) can enter the brain through the BBB.
    Onjisaponin B
  • HY-N2456
    Mogroside IV-E 88915-64-4 99.71%
    Mogroside IV-E, a triterpenoid glycoside, is a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities.
    Mogroside IV-E
  • HY-N2555
    Tilianin 4291-60-5 99.67%
    Tilianin is an active flavonoid glycoside found in many medical plants, with potential anti-hypertensive, myocardial-protective, anti-diabetic, anti-hyperlipidemic, anti-inflammatory and antioxidant effects.
    Tilianin
  • HY-N2582
    Calcium Phytate 3615-82-5 98.0%
    Calcium phytate (Phytin) is an insoluble phosphorus-containing compound widely present in plant-based foods such as cereals and legumes. Calcium phytate can be found in feces and can alleviate lead poisoning.
    Calcium Phytate
  • HY-N2673
    5-Heptadecylresorcinol 41442-57-3 99.83%
    5-Heptadecylresorcinol (AR-C17), a phenolic lipid component, is also an orally active mitochondrial protector. 5-Heptadecylresorcinol improves mitochondrial function via sirtuin3 signaling pathway, thus alleviates endothelial cell damage and apoptosis. 5-Heptadecylresorcinol induces sirtuin3-mediated autophagy. 5-Heptadecylresorcinol reduces the atherosclerotic plaques in the aortic root region of mice heart. 5-Heptadecylresorcinol can be used for research of atherosclerosis prevention and obesity.
    5-Heptadecylresorcinol
  • HY-N2923
    β-Amyrin acetate 1616-93-9 99.89%
    β-Amyrin acetate is a triterpenoid with potent anti-inflammatory, antifungal, anti-diabetic, anti-hyperlipidemic activities. β-Amyrin acetate can inhibit HMG-CoA reductase activity by locating in the hydrophobic binding cleft of HMG CoA reductase.
    β-Amyrin acetate
  • HY-N4110
    Friedelin 559-74-0 ≥98.00%
    Friedelin is derived from the leaves of Maytenus ilicifolia (Mart). Friedelin is an orally active non-competitive inhibitor of CYP3A4, with IC50 and Ki values of 10.79 μM and 6.16 μM, respectively. Friedelin is also a competitive inhibitor of CYP2E1, with IC50 and Ki values of 22.54 μM and 18.02 μM, respectively. Friedelin can be used in research related to inflammation, neurological diseases, and metabolic disorders.
    Friedelin
  • HY-N5092
    7-Methylcoumarin 2445-83-2 99.93%
    7-Methylcoumarin is a coumarin derivative with potent hepatoprotective and antioxidant properties. 7-Methylcoumarin is a mechanism-based inhibitor for CYP2A6. 7-Methylcoumarin significantly decreases alanine aminotransferase (ALT), aspartate aminotransferase (AST), and serum bilirubin (TB) in rats with CCl4-induced liver damage, whilst restoring total protein (TP) and albumin (TA) levels in serum as well as preventing oxidative stress. 7-Methylcoumarin can decline mitotic activity of A. sativum promeristem.
    7-Methylcoumarin
  • HY-N6858
    4-Hydroxyisoleucine 781658-23-9 ≥98.0%
    4-Hydroxyisoleucine is an orally active amino acid that can be isolated from fenugreek seeds. 4-Hydroxyisoleucine displays insulinotropic and antidiabetic properties.
    4-Hydroxyisoleucine
  • HY-N6924
    Zingibroside R1 80930-74-1 99.75%
    Zingibroside R1 is an orally active triterpene saponin with multiple biological activities including antioxidant, anti-inflammatory, antiviral, and metabolic regulatory properties. Zingibroside R1 reduces the expression of PIN family members, inhibits the expression of PLT1/PLT2, WOX5, SHR, and SCR, disrupts auxin transport and distribution, triggers plant ROS responses, and inhibits root growth. Zingibroside R1 extends the lifespan of Caenorhabditis elegans, enhances its heat stress resistance, and improves its motor ability. Hydrogel derivatives of Zingibroside R1 inhibit the proliferation of Candida albicans by binding to its β-1,3-glucan and exhibit antifungal activity. Zingibroside R1 inhibits GLUT1-mediated uptake and alleviates liver injury. Zingibroside R1 can be used in research related to neurodegenerative diseases, vulvovaginal candidiasis, acute liver injury, Ehrlich ascites tumor and HIV-1 infection.
    Zingibroside R1
  • HY-N6942
    Mogroside IV-A 88901-41-1 99.9%
    Mogroside IV-A, a triterpenoid glycoside isolated from the extracts of Luo Han Guo, is a nonsugar sweetener. Mogrosides are sweeter than sucrose. Mogrosides exhibit antioxidant, antidiabetic and anticancer activities.
    Mogroside IV-A
  • HY-N6951
    Guaiazulene 489-84-9 ≥98.0%
    Guaiazulene is a bicyclic sesquiterpene. Guaiazulene exhibits various biological activities such as anti-inflammatory, antioxidant, hepatoprotective, antibacterial, and anti-tumor properties. Guaiazulene is also commonly used as a colorant in cosmetics. Guaiazulene shows in vitro cytotoxicity to rat neuronal cells and N2a neuroblastoma cells at high concentrations.
    Guaiazulene
  • HY-N7072
    Grape seed extract 84929-27-1
    Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells.
    Grape seed extract
  • HY-N9536
    Cinnamtannin A2 86631-38-1
    Cinnamtannin A2, a tetrameric procyanidin, can increases GLP-1 and insulin secretion in mice. Cinnamtannin A2 could upregulate the expression of corticotrophin releasing hormone. Cinnamtannin A2 exhibits antioxidant, anti-diabetic and nephroprotective effect.
    Cinnamtannin A2
  • HY-P0179
    β-Casomorphin, bovine 72122-62-4 99.89%
    β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay.
    β-Casomorphin, bovine
  • HY-P2733
    Glycerol-3-phosphate oxidase, E. coli 9046-28-0
    Glycerol-3-phosphate oxidase, E. coli (GPO) is a key intermediate in glycerol metabolism. Glycerol-3-phosphate oxidase, E. coli is the skeleton of phospholipids in membrane lipids, and also a substrate in the respiratory chain. Glycerol-3-phosphate oxidase, E. coli produces electrons through oxidation. Glycerol-3-phosphate oxidase, E. coli is an enzyme with important functions in the field of biochemistry, and is widely used in medical testing and scientific research.
    Glycerol-3-phosphate oxidase, E. coli
  • HY-P3651
    Cholecystokinin (26-33) free acid 103974-46-5
    Cholecystokinin (26-33) (CCK (26-33)) free acid is a cholecystokinin (CCK) fragment. Cholecystokinin (26-33) free acid can reduce food intake and gallbladder contraction.
    Cholecystokinin (26-33) free acid
  • HY-P5247
    Palmitoyl tetrapeptide-20 99.21%
    Palmitoyl tetrapeptide-20 (PTP20) is a biomimetic peptide agonist of α-MSH. Palmitoyl tetrapeptide-20 promotes hair pigmentation and delays hair graying by activating the MC1-R pathway (AC50: 0.16 nM), enhancing catalase activity to reduce H2O2 accumulation, and upregulating SIRT1 activity. Palmitoyl tetrapeptide-20 can be used in research on preventing hair loss and improving hair graying.
    Palmitoyl tetrapeptide-20
  • HY-Y0095
    Isethionic acid (80% in water) 107-36-8
    Isethionic acid is a calcium binder and anionic detergent that enhances mitochondrial calcium binding capacity by competitively binding to calcium binding sites on the outer mitochondrial membrane. Isethionic acid can inhibit calcium-activated mitochondrial respiration. Isethionic acid inhibits barnacle (Balanus amphitrite) larvae with LC50s of 23 μg/mL (24 h) and 17 μg/mL (48 h), respectively. Isethionic acid can inhibit the attachment of barnacle larvae (complete inhibition at 10 μg/mL) and regulate mitochondrial calcium transport, and can enhance ATP-dependent calcium uptake at high calcium concentrations. Isethionic acid can be used to study the mechanism of mitochondrial calcium metabolism.
    Isethionic acid (80% in water)
  • HY-100459
    GSK3179106 1627856-64-7 99.81%
    GSK3179106 is an orally active and selective RET kinase inhibitor with IC50s of 0.4 nM, 0.2 nM for human RET and rat RET, respectively. GSK3179106 has the potential for irritable bowel syndrome (IBS) through the attenuation of post-inflammatory and stress-induced visceral hypersensitivity.
    GSK3179106
Cat. No. Product Name / Synonyms Application Reactivity